Endocrine Abstracts

Background: The incidence of hypophysitis has increased since the introduction of Immuno-oncologic treatment. Treatment with anti-CTLA-4 (Ipilimumab) and anti-PD-1 has improved the prognosis for patients with malign melanoma drastically, but immune-mediated side effects can occur in any organ, including the thyroid and the pituitary. Headache is considered a key symptom of hypophysitis. Here, we report three cases with silent, isolated ACTH-insufficiency following immunotherap...

Background: Secondary hyperparathyroidism (SHPT) is severe complication of chronic kidney disease, characterized by high serum parathyroid hormone (PTH), parathyroid gland hyperplasia, and disturbances in mineral metabolism. Effective management of SHPT includes measures to prevent hyperphosphataemia and excess PTH, to maintain serum calcium within the normal range. In dialysis patients with severe SHPT, medical treatment may fail and parathyroidectomy (PTX) is indicated for d...

JQ1 is a bromodomain inhibitor that specifically targets the BET protein family (comprising Brd2, Brd3, Brd4 and BrdT), which promote the transcription of genes by binding acetylated histone residues and recruiting transcriptional machinery. JQ1 has been shown to have efficacy in the treatment of neuroendocrine tumours, however the genes regulated by the BET family in endocrine tissues, particularly in the pituitary, have not been elucidated. We therefore performed RNA-Seq ana...